Not really. You could edit all the css to percentages but then as soon as someone uses a phone or tablet you won't see a thing. It also means that on very large screens your content will be too wide. Perhaps even having paragraphs display on a single line.
You would be better off using one of the responsive templates.
Hope this helps
Please search forums before posting. Please make sure your post includes the version of the CMS you are using and a link to the problem. Annotations on screenshots can also be helpful to explain problems/goals. Please use the "secure" tab for confidential information